In a world where brain injuries and strokes remain among the leading causes of disability, the search for new treatments is not just relevant, but critical. Traditional methods of rehabilitation have their limitations, and pharmacological approaches often fail to produce the expected results or are accompanied by significant side effects. However, a new player is emerging on the horizon - psychedelics, which have begun to be seen not only as a means of expanding consciousness, but also as potential therapeutic tools.
Why psychedelics?
One of the key questions is why psychedelics? The answer lies in their unique ability to influence the brain's neural networks. Psychedelics such as ketamine, psilocybin (from mushrooms), LSD, MDMA, and DMT are known for their ability to alter perception, mood, and consciousness. But now, researchers are focusing on their ability to promote neuroplasticity - the brain's ability to form new neural connections. This may be the key to restoring function after injuries or strokes, when part of the brain is damaged or has lost its function.
Neuroplasticity and reduction of inflammation
Psychedelics can activate the 5-HT2A serotonin receptor, which is thought to play a role in neuroplasticity. This means that they can support the brain in "reprogramming," allowing healthy areas of the brain to take over the functions of affected ones. Additionally, some psychedelics have shown potential in reducing inflammation, which is often a companion to brain injuries and strokes. Inflammation can lead to secondary damage, and controlling it is essential to recovery.
Practical research and results
Although much of the research is still in its early stages, some clinical trials have already shown promising results. For example, MDMA has been studied as a means to reduce fear and anxiety in patients after trauma, which can facilitate the rehabilitation process. Psilocybin is being researched to improve mood and reduce depression, which often accompanies brain injuries. Animal experiments have also shown that psychedelics can improve motor and cognitive function after a stroke.
Security and challenges
The use of psychedelics in medicine is not without its challenges. The main ones include safety, dosage, and control over the psychedelic experience. Psychedelic substances can cause severe hallucinations and perceptual changes, which requires careful monitoring. In addition, there is a need to create protocols that would reduce the risks associated with their use, especially in the context of patients with mental disorders or a history of psychosis.
The future of psychedelic therapy
The future of psychedelic therapy in the treatment of brain injury looks promising. Research is now actively underway to develop new drugs or methods of administration that would retain the therapeutic benefits of psychedelics without their potentially dangerous side effects. This may include microdosing, where patients receive very small doses that do not cause hallucinations but can help restore neural connections.
Ethical and legal aspects
One of the biggest barriers to psychedelic research is its legal status in many countries. However, changing public attitudes toward these substances and growing scientific interest are beginning to change policy. Most studies are conducted in controlled clinical trials, which allows psychedelics to be studied without violating current legislation.
Conclusion.
Psychedelics are opening up new horizons in the treatment of brain injuries, promising not just symptomatic relief but also restoration of function through stimulation of neuroplasticity and control of inflammation. Although the science faces significant challenges, including safety, dosage, and public acceptance, the first steps have already been taken. Perhaps in the future, psychedelics will become a common part of medical practice, allowing people after strokes or brain injuries to live a full life.
Based on materials from frontiersin.org
