In a world where brain injuries and strokes remain among the leading causes of disability, the search for new treatments is not just urgent, but critically important. Traditional rehabilitation methods have their limitations, and pharmacological approaches often fail to produce the expected results or are accompanied by significant side effects. However, a new player is emerging on the horizon: psychedelics, which have begun to be viewed not only as means of expanding consciousness, but also as potential therapeutic tools.
Why psychedelics?
One of the key questions is why psychedelics? The answer lies in their unique ability to affect the neural networks of the brain. Psychedelics, such as ketamine, psilocybin (from mushrooms), LSD, MDMA, and DMT, are known for their ability to alter perception, mood, and consciousness. But researchers are now focusing on their ability to promote neuroplasticity—the brain’s ability to form new neural connections. This may be key to restoring function after injuries or strokes, when parts of the brain are damaged or have lost function.
Neuroplasticity and reducing inflammation
Psychedelics can activate serotonin 5-HT2A receptors, which are thought to play a role in neuroplasticity. This means they can help the brain “reprogram itself,” allowing healthy areas of the brain to take over the functions of damaged ones. Additionally, some psychedelics have shown potential in reducing inflammation, which often accompanies brain injuries and strokes. Inflammation can lead to secondary damage, and controlling it is important for recovery.
Practical research and results
Although much of the research is still in its early stages, some clinical trials have already shown promising results. For example, MDMA has been studied as a means of reducing fear and anxiety in patients after trauma, which may facilitate the rehabilitation process. Psilocybin is being studied for improving mood and reducing depression, which often accompanies brain injuries. Animal experiments have also shown that psychedelics can improve motor and cognitive function after stroke.
Security and challenges
The use of psychedelics in medicine is not without challenges. The main ones include safety, dosage, and control over the psychedelic experience. Psychedelics can cause intense hallucinations and perceptual changes, which require careful monitoring. In addition, there is a need to create protocols that reduce the risks associated with their use, especially in the context of patients with mental disorders or a history of psychosis.
The future of psychedelic therapy
The future of psychedelic therapy in the treatment of brain injuries looks promising. Research is currently underway to develop new drugs or methods of administration that retain the therapeutic benefits of psychedelics without their potentially dangerous side effects. This could include microdosing, where patients are given very small doses that do not cause hallucinations but may help restore neural connections.
Ethical and legal aspects
One of the biggest barriers to research on psychedelics is their legal status in many countries. However, changing public attitudes towards these substances and growing scientific interest are beginning to change policy. Most research is conducted in controlled clinical trials, which allows psychedelics to be studied without violating existing laws.
Conclusion
Psychedelics are opening up new horizons in the treatment of brain injuries, promising not just symptomatic relief but also restoration of function through stimulation of neuroplasticity and control of inflammation. Although significant challenges remain, including safety, dosing, and public acceptance, the first steps have been taken. Perhaps in the future, psychedelics will become a routine part of medical practice, allowing people after strokes or brain injuries to live full lives.
Based on materials from frontiersin.org
